Biological aging of CNS-resident cells alters the clinical course and immunopathology of autoimmune demyelinating disease
Biological aging is the strongest factor associated with the clinical phenotype of multiple sclerosis (MS).Relapsing-remitting MS typically presents in the third or fourth decade, whereas the mean age of presentation of progressive MS (PMS) is 45 years old.Here, we show that experimental autoimmune encephalomyelitis (EAE), induced by the adoptive t